Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

Esperanza Romero Fernández; Guillermo Montalbán Bravo; Rosario Arrieta Gallastegui; Ana Rodríguez De la Rúa Fernández

doi:10.1016/j.lrr.2013.06.002

Lymphocyte recovery and infused CD34+ cells dose: Effect on the evolution after stem cell autotransplantation

Leuk Res Rep. 2013 Jul 15;2(2):54-7. doi: 10.1016/j.lrr.2013.06.002. eCollection 2013.

Authors

Esperanza Romero Fernández¹, Guillermo Montalbán Bravo¹, Rosario Arrieta Gallastegui¹, Ana Rodríguez De la Rúa Fernández¹

Affiliation

¹ Hematology Department, University Hospital La Paz, Paseo de la Castellana 261, C. P. 28046 Madrid, Spain.

Abstract

Background and objective: The number of infused CD34+cells (CD34+i) has been associated with absolute lymphocyte count (ALC) and the outcome undergoing autologous hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. The study's aim was to analyze the relationship between CD34+i, ALC and prognosis in this patients.

Patients and method: Medical records of 163 patients receiving HSCT between 2005 and 2012 were reviewed.

Results: We found significant and inversely proportional relationship between the CD34+i and the days required to reach ALC≥500/μl according to the regression line: days=-0.981×number of CD34+i+18.09.

Conclusions: We have obtained a predictive model of lymphocyte recovery based recovery of CD34+i.

Keywords: Infused CD34+ cells; Inmune reconstitution; Lymphocyte recovery; Prognosis; Stem cell autotransplantation.