Coexisting atypical polypoid adenomyoma and endometrioid endometrial carcinoma in a young woman with Cowden Syndrome: Case report and implications for screening and prevention

James M Edwards; Skylar Alsop; Susan C Modesitt

doi:10.1016/j.gynor.2011.12.004

Coexisting atypical polypoid adenomyoma and endometrioid endometrial carcinoma in a young woman with Cowden Syndrome: Case report and implications for screening and prevention

Gynecol Oncol Case Rep. 2012 Jan 5;2(2):29-31. doi: 10.1016/j.gynor.2011.12.004. eCollection 2012.

Authors

James M Edwards¹, Skylar Alsop², Susan C Modesitt³

Affiliations

¹ Department of Obstetrics and Gynecology, Duke University Medical Center, DUMC Box 3616, Durham, NC, USA.
² Department of Pathology, Maryview Medical Center, 3636 High Street, Portsmouth, VA 23707, USA.
³ Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia, PO Box 800712, Charlottesville, VA 22908, USA.

Abstract

► Cowden Syndrome is a rare hereditary cancer syndrome, which confers an increased risk of breast, thyroid, endometrial and colon cancer. ► Atypical polypoid adenomyoma does not generally represent a premalignant lesion, but must be carefully screened for foci of malignancy. ► Cancer screening must be intensified for patients who meet the diagnostic criteria for Cowden Syndrome.

Keywords: Atypical polypoid adenocarcinoma; Cowden Syndrome; Endometrial cancer.