Abstract
Three new thiodiketopiperazines, named phomazines A-C (1-3), along with 10 known analogues (4-13), were isolated from the fermentation broth of an endophytic fungus, Phoma sp. OUCMDZ-1847, associated with the mangrove plant Kandelia candel. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic, X-ray crystallographic, and Mosher's methods along with quantum ECD and (13)C NMR calculations. Compounds 2, 4, 5, 11, and 12 showed cytotoxicities against the HL-60, HCT-116, K562, MGC-803, and A549 cell lines with IC50 values in the range 0.05 to 8.5 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Ascomycota / chemistry*
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China
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HCT116 Cells
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HL-60 Cells
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Humans
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Inhibitory Concentration 50
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K562 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Piperazines / chemistry
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Piperazines / isolation & purification*
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Piperazines / pharmacology
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Rhizophoraceae / microbiology
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Sulfur Compounds / chemistry
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Sulfur Compounds / isolation & purification*
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Sulfur Compounds / pharmacology
Substances
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Antineoplastic Agents
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Piperazines
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Sulfur Compounds
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phomazine A
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phomazine B
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phomazine C