Mucoadhesivity and release properties of quaternary ammonium-chitosan conjugates and their nanoparticulate supramolecular aggregates: an NMR investigation

Int J Pharm. 2014 Jan 30;461(1-2):489-94. doi: 10.1016/j.ijpharm.2013.12.018. Epub 2013 Dec 22.

Abstract

Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium-chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone loaded nanoparticles was defined by quantitative NMR and interrupted dialysis experiments, and mucoadhesivity of empty nanoparticles was effectively probed by selective relaxation rate measurements.

Keywords: Chitosan conjugates; Dynamic dialysis; Interrupted dialysis; Nanoparticles; Nuclear magnetic resonance; Selective relaxation rate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Animals
  • Cattle
  • Chitosan / chemistry*
  • Dexamethasone / analogs & derivatives*
  • Dexamethasone / chemistry
  • Dialysis
  • Magnetic Resonance Spectroscopy / methods*
  • Mucins / metabolism
  • Nanoparticles
  • Quaternary Ammonium Compounds / chemistry*

Substances

  • Mucins
  • Quaternary Ammonium Compounds
  • dexamethasone 21-phosphate
  • Dexamethasone
  • Chitosan