Helicobacter pylori and interleukin-8 in gastric cancer

Ko Eun Lee; Pham Ngoc Khoi; Yong Xia; Jung Sun Park; Young Eun Joo; Kyung Keun Kim; Seok Yong Choi; Young Do Jung

doi:10.3748/wjg.v19.i45.8192

Helicobacter pylori and interleukin-8 in gastric cancer

World J Gastroenterol. 2013 Dec 7;19(45):8192-202. doi: 10.3748/wjg.v19.i45.8192.

Authors

Ko Eun Lee¹, Pham Ngoc Khoi¹, Yong Xia¹, Jung Sun Park¹, Young Eun Joo¹, Kyung Keun Kim¹, Seok Yong Choi¹, Young Do Jung¹

Affiliation

¹ Ko Eun Lee, Pham Ngoc Khoi, Yong Xia, Jung Sun Park, Young Eun Joo, Kyung Keun Kim, Seok Yong Choi, Young Do Jung, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-190, South Korea.

Abstract

Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.

Keywords: Gastric cancer; Helicobacter pylori; Interleukin-8; Signals; Therapeutics.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use
Cell Transformation, Neoplastic / chemically induced
Cell Transformation, Neoplastic / immunology
Cell Transformation, Neoplastic / metabolism
Drug Design
Gastric Mucosa / immunology
Gastric Mucosa / metabolism*
Gastric Mucosa / microbiology*
Helicobacter Infections / epidemiology
Helicobacter Infections / immunology
Helicobacter Infections / metabolism*
Helicobacter Infections / microbiology*
Helicobacter pylori / immunology
Helicobacter pylori / pathogenicity*
Humans
Interleukin-8 / antagonists & inhibitors
Interleukin-8 / metabolism*
Molecular Targeted Therapy
Prognosis
Receptors, Interleukin-8 / antagonists & inhibitors
Receptors, Interleukin-8 / metabolism
Risk Factors
Signal Transduction
Stomach Neoplasms / immunology
Stomach Neoplasms / metabolism*
Stomach Neoplasms / microbiology*

Substances

Antineoplastic Agents
CXCL8 protein, human
Interleukin-8
Receptors, Interleukin-8