Darunavir and telaprevir drug interaction: total and unbound plasma concentrations in HIV/HCV-coinfected patients with cirrhosis

J Antimicrob Chemother. 2014 May;69(5):1434-6. doi: 10.1093/jac/dkt509. Epub 2013 Dec 19.
No abstract available

Keywords: antiretroviral treatment; hepatic cirrhosis; pharmacokinetics.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacokinetics*
  • Antiviral Agents / therapeutic use
  • Darunavir
  • Drug Interactions*
  • Female
  • HIV Infections / drug therapy*
  • Hepatitis C, Chronic / complications
  • Hepatitis C, Chronic / drug therapy*
  • Humans
  • Liver Cirrhosis*
  • Male
  • Middle Aged
  • Oligopeptides / pharmacokinetics*
  • Oligopeptides / therapeutic use
  • Plasma / chemistry
  • Sulfonamides / pharmacokinetics*
  • Sulfonamides / therapeutic use

Substances

  • Antiviral Agents
  • Oligopeptides
  • Sulfonamides
  • telaprevir
  • Darunavir