The role of gene-gene interaction in the prediction of criminal behavior

Compr Psychiatry. 2014 Apr;55(3):483-8. doi: 10.1016/j.comppsych.2013.11.005. Epub 2013 Nov 18.

Abstract

A host of research has examined the possibility that environmental risk factors might condition the influence of genes on various outcomes. Less research, however, has been aimed at exploring the possibility that genetic factors might interact to impact the emergence of human traits. Even fewer studies exist examining the interaction of genes in the prediction of behavioral outcomes. The current study expands this body of research by testing the interaction between genes involved in neural transmission. Our findings suggest that certain dopamine genes interact to increase the odds of criminogenic outcomes in a national sample of Americans.

MeSH terms

  • Adult
  • Criminals / psychology*
  • Epistasis, Genetic*
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Receptors, Dopamine D2 / genetics*
  • Receptors, Dopamine D4 / genetics*
  • Risk Factors

Substances

  • DRD2 protein, human
  • DRD4 protein, human
  • Receptors, Dopamine D2
  • Receptors, Dopamine D4