Probing DNA by 2-OG-dependent dioxygenase

Chi-Lin Tsai; John A Tainer

doi:10.1016/j.cell.2013.12.002

Probing DNA by 2-OG-dependent dioxygenase

Cell. 2013 Dec 19;155(7):1448-50. doi: 10.1016/j.cell.2013.12.002.

Authors

Chi-Lin Tsai¹, John A Tainer²

Affiliations

¹ Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
² Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Molecular Biology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: jat@scripps.edu.

Abstract

TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

5-Methylcytosine / metabolism*
DNA / chemistry*
DNA / metabolism*
DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / metabolism*
Dioxygenases
Humans
Proto-Oncogene Proteins / chemistry*
Proto-Oncogene Proteins / metabolism*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
5-Methylcytosine
DNA
Dioxygenases
TET2 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding