Abstract
Highlight describes the recently discovered prodrug activation mechanism found in the biosynthesis of nonribosomally produced peptides and peptide/polyketide hybrids as well as related mechanisms.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Bacterial Agents / biosynthesis
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Anti-Bacterial Agents / chemistry
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Bacteria / chemistry
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Bacteria / enzymology*
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Molecular Structure
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Peptide Biosynthesis
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Peptide Synthases / metabolism*
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Polyketide Synthases / metabolism*
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Prodrugs / chemistry
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Prodrugs / metabolism
Substances
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Anti-Bacterial Agents
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Prodrugs
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Polyketide Synthases
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Peptide Synthases
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non-ribosomal peptide synthase