A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides

Nat Prod Rep. 2014 Jan 17;31(2):154-9. doi: 10.1039/c3np70081j.

Abstract

Highlight describes the recently discovered prodrug activation mechanism found in the biosynthesis of nonribosomally produced peptides and peptide/polyketide hybrids as well as related mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / chemistry
  • Bacteria / chemistry
  • Bacteria / enzymology*
  • Molecular Structure
  • Peptide Biosynthesis
  • Peptide Synthases / metabolism*
  • Polyketide Synthases / metabolism*
  • Prodrugs / chemistry
  • Prodrugs / metabolism

Substances

  • Anti-Bacterial Agents
  • Prodrugs
  • Polyketide Synthases
  • Peptide Synthases
  • non-ribosomal peptide synthase