The neuroepithelium has been used as an experimental model to find biological markers for neuropsychiatric disease diagnosis. Patent information permits understanding of the state of the art of neuroepithelium in neuropsychiatric disease diagnosis, as well as the identification of trends in research and development on this theme. In this article, we discuss diverse methods for obtaining primary cultures of olfactory neurons obtained by animal dissection or by postmortem biopsy of human cadavers. The principal owners of patents related to olfactory neuroepithelia are universities such as John Hopkins and Bristol-Myers Squibb. The USA has the most research lines and approved patents in the world, while Rutgers, the State University of New Jersey, provides composition and methods related to the diagnoses and treatment of neuropsychiatric disorders.