Abstract
Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Ascomycota / chemistry*
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Cell Line, Tumor
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Circular Dichroism
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HCT116 Cells
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Heterocyclic Compounds, Bridged-Ring / chemistry
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Heterocyclic Compounds, Bridged-Ring / isolation & purification*
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Heterocyclic Compounds, Bridged-Ring / pharmacology
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / chemistry
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Polyketides / isolation & purification*
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Polyketides / pharmacology
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Tibet
Substances
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Antineoplastic Agents
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Heterocyclic Compounds, Bridged-Ring
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Polyketides