Does multiple sclerosis affect glucose tolerance?

Mult Scler. 2014 Aug;20(9):1273-6. doi: 10.1177/1352458513515957. Epub 2013 Dec 17.

Abstract

Based on current literature, it is not clear if multiple sclerosis (MS) patients are at increased risk to develop impaired glucose tolerance (IGT). Eighty-one MS patients and 45 healthy controls (HC) performed an oral glucose tolerance test. IGT was defined as a fasting glucose concentration of 6.1-6.9 mmol/l and two-hour post-load glucose of 7.8-11.1 mmol/l. The prevalence of impaired fasting glucose concentrations (17% vs 2%) and IGT (11% vs 0%) was higher in MS patients than HC. Accordingly, the areas under the glucose and insulin curves were higher in MS patients. The current study demonstrates an elevated IGT-prevalence in MS.

Keywords: Impaired glucose tolerance; diabetes type II; insulin; multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Belgium / epidemiology
  • Biomarkers / blood
  • Blood Glucose / metabolism*
  • Case-Control Studies
  • Cross-Sectional Studies
  • Fasting / blood
  • Female
  • Glucose Intolerance / blood*
  • Glucose Intolerance / diagnosis
  • Glucose Intolerance / epidemiology
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / diagnosis
  • Multiple Sclerosis / epidemiology
  • Predictive Value of Tests
  • Prevalence
  • ROC Curve
  • Risk Factors
  • Time Factors

Substances

  • Biomarkers
  • Blood Glucose
  • Insulin