Borderline tuberculoid leprosy and type 1 leprosy reaction in a hepatitis C patient during treatment with interferon and ribavirin

An Bras Dermatol. 2013 Nov-Dec;88(6 Suppl 1):109-12. doi: 10.1590/abd1806-4841.20131986.

Abstract

Hepatitis C is an inflammatory disease of the liver caused by a single-stranded RNA virus belonging to the Hepacivirus genus in the Flaviviridae family, called the hepatitis C virus. After initial infection, 70% to 85% of the patients develop chronic hepatitis C with hepatic fibrosis. In addition to specific liver changes, various extrahepatic manifestations have been associated with the hepatitis C virus infection or with medications used to treat the condition. We report the case of a patient with chronic hepatitis C who presented with the signs and symptoms of borderline tuberculoid leprosy and type 1 reaction four months after the start of treatment with a pegylated interferon/ribavirin combination.

A hepatite C é uma doença inflamatória fígado causada por um vírus RNA de fita simples, pertencente ao gênero Hepacivirus e à família Flaviviridae, denominado de vírus da hepatite C. Após infecção inicial 70 a 85% dos pacientes infectados evoluem para hepatite C crônica, com fibrose progressiva. Além das alterações hepáticas específicas, várias manifestações extra-hepáticas têm sido relacionadas à infecção pelo vírus da hepatite C ou às medicações utilizadas no seu tratamento. Nesse trabalho, apresenta-se caso de paciente portador de hepatite C crônica, que manifestou um quadro hanseníase boderline tuberculóide e reação hansênica do tipo I, quatro meses após início do tratamento com interferon peguilado associado à ribavirina.

Publication types

  • Case Reports

MeSH terms

  • Acute-Phase Reaction / chemically induced
  • Antiviral Agents / adverse effects*
  • Drug Therapy, Combination / adverse effects
  • Hepatitis C / complications
  • Hepatitis C / drug therapy*
  • Humans
  • Interferons / adverse effects*
  • Leprosy, Borderline / chemically induced*
  • Leprosy, Borderline / pathology
  • Leprosy, Tuberculoid / chemically induced*
  • Leprosy, Tuberculoid / pathology
  • Male
  • Middle Aged
  • Ribavirin / adverse effects*

Substances

  • Antiviral Agents
  • Ribavirin
  • Interferons