Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

Chem Commun (Camb). 2014 Feb 9;50(11):1369-71. doi: 10.1039/c3cc48130a.

Abstract

Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / chemistry*
  • Drug Delivery Systems*
  • Ferric Compounds / chemistry
  • Fluorescent Dyes / chemistry
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Jurkat Cells
  • Lactic Acid / chemistry
  • Nanoparticles / chemistry*
  • Perylene / analogs & derivatives
  • Perylene / chemistry
  • Polyesters
  • Polymers / chemistry

Substances

  • Ferric Compounds
  • Fluorescent Dyes
  • N-(2,6-diisopropylphenyl)perylene-3,4-dicarboximine
  • Polyesters
  • Polymers
  • ferric oxide
  • Lactic Acid
  • poly(lactide)
  • Perylene