Pulmonary arterial hypertension in HIV infection: a concise review

Hai-Long Dai; Ming Zhang; Zhi-Cheng Xiao; Xue-Feng Guang; Xiao-Long Yin

doi:10.1016/j.hlc.2013.10.088

Pulmonary arterial hypertension in HIV infection: a concise review

Heart Lung Circ. 2014 Apr;23(4):299-302. doi: 10.1016/j.hlc.2013.10.088. Epub 2013 Oct 31.

Authors

Hai-Long Dai¹, Ming Zhang², Zhi-Cheng Xiao³, Xue-Feng Guang⁴, Xiao-Long Yin⁵

Affiliations

¹ Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, PR China; The Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, PR China; Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia.
² The Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, PR China.
³ The Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, PR China; Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia.
⁴ Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, PR China. Electronic address: zwdfc168@sohu.com.
⁵ Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, Kunming, PR China.

PMID: 24345377
DOI: 10.1016/j.hlc.2013.10.088

Abstract

Pulmonary arterial hypertension (PAH) is an infrequent but nevertheless serious life threatening severe complication of human immunodeficiency virus (HIV) infection. In today's era of antiretroviral therapy (ART), the mortality of HIV patients has greatly reduced due to improved immune function and fewer opportunistic infections. However, these patients have an increased incidence of PAH. In this review, we will mainly discuss HIV-related pulmonary arterial hypertension (HRPH) in terms of the epidemiology, pathogenesis, clinical characteristics and treatment.

Keywords: Aetiology; HIV; Hypertension; Pulmonary; Therapeutics.

Copyright © 2013 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

HIV Infections* / complications
HIV Infections* / epidemiology
HIV Infections* / pathology
HIV Infections* / physiopathology
HIV Infections* / therapy
HIV-1*
Humans
Hypertension, Pulmonary* / epidemiology
Hypertension, Pulmonary* / etiology
Hypertension, Pulmonary* / pathology
Hypertension, Pulmonary* / therapy