1 1 School of Chinese Medicine China Medical University Taichung, Taiwan 2 Department of Pediatrics China Medical University Hospital Taichung, Taiwan 3 Department of Pediatrics Taoyuan General Hospital Taoyuan, Taiwan 4 Department of Pediatrics Chung Shan Medical University Hospital Taichung, Taiwan 5 Institute of Medicine Chung Shan Medical University Taichung, Taiwan 6 School of Medicine Chung Shan Medical University Taichung, Taiwan 7 Division of Allergy, Asthma and Rheumatology Department of Pediatrics Chang Gung Memorial Hospital Taoyuan, Taiwan.