Multi-level and multi-scale integrative approach to the understanding of human blastocyst implantation

Abstract

Implantation is a complex process which results in fixation of zona pellucida free blastocyst to the maternal uterine endometrium. In the human, it involves progesterone mediated preparation of endometrium, age- and stage-matched development of pre-implantation embryo, and interaction between embryo and endometrium. In the present essay, we present the case to explain why there is a necessity of undertaking multi-level, multi-scale integrative approach to deconstruct the succession process of endometrial development to the climax of implantation.

Keywords: Blastocyst; Endometrium; Implantation; Informational networks; Receptivity.