[The role of genetic factors in the development of chronic dust bronchitis in workers of coal mining enterprises of Kuzbass]

Gig Sanit. 2013 Jul-Aug:(4):44-7.
[Article in Russian]

Abstract

The distribution of genotypes of HP, GC, EsD, AsP and polymorphisms GSTT1 (GST-theta1) and GSTM1 (GST-micro1) and NOS3 (polymorphism VNTR4) in miners with chronic dust bronchitis, and in those without this occupational disease has been studied The carriers of genotypes of genotypes EsD 1-2, AsP bb were shown to be more prone to develop chronic dust bronchitis. Endogenous factors of resistance to the disease are the genotypes GC 1-1, EsD 1-1, AsP bc.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Air Pollutants, Occupational / toxicity*
  • Bronchitis, Chronic / chemically induced
  • Bronchitis, Chronic / genetics*
  • Case-Control Studies
  • Coal Mining*
  • Dust*
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione Transferase / genetics
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide Synthase Type III / genetics
  • Occupational Diseases / chemically induced
  • Occupational Diseases / genetics*
  • Polymorphism, Genetic
  • Siberia

Substances

  • Air Pollutants, Occupational
  • Dust
  • NOS3 protein, human
  • Nitric Oxide Synthase Type III
  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1