Synthesis of metal nanoparticles inside living human cells based on the intracellular formation process

Adv Mater. 2014 Feb 12;26(6):910-8. doi: 10.1002/adma.201303699. Epub 2013 Dec 16.

Abstract

Intracellular and extracellular formation of Au and Ag NPs with different sizes and shapes using human cells has been developed as green method, which does not require the use of any reducing agents. Also, the cell lysis is used for production of different metal NPs. Our results demonstrate that treatment of human cells with various metal ions cause cell fixation.

Keywords: Raman spectroscopy; intracellular formation process; living human cells; metal nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / chemistry
  • Cell Nucleus Shape
  • Cell Shape
  • Cytoplasm / chemistry
  • Cytoplasm / drug effects
  • Enzyme Inhibitors / pharmacology
  • Extracellular Space / chemistry*
  • Gold Compounds / chemistry*
  • Green Chemistry Technology
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Indolequinones / pharmacology
  • Intracellular Space / chemistry*
  • Intracellular Space / drug effects
  • MCF-7 Cells
  • Metal Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Rotenone / pharmacology
  • Silver Compounds / chemistry*
  • Silver Nitrate / chemistry

Substances

  • 5-methoxy-1,2-dimethyl-3-((4-nitrophenoxy)methyl)indole-4,7-dione
  • Enzyme Inhibitors
  • Gold Compounds
  • Indolequinones
  • Silver Compounds
  • Rotenone
  • gold chloride
  • Silver Nitrate