Fly model causes neurological rethink

Elife. 2013 Dec 11:2:e01820. doi: 10.7554/eLife.01820.

Abstract

A Drosophila model for a neurological disorder called type 2B Charcot-Marie-Tooth disease reveals that it has its origins in a partial loss of function, rather than a gain of function, which points to the need for a new therapeutic approach.

Keywords: animal models of disease; endosome; genetics; neuropathy; synapse.

Publication types

  • Comment

MeSH terms

  • Animals
  • Charcot-Marie-Tooth Disease / genetics*
  • Laminopathies
  • Mutation*
  • Neurodegenerative Diseases / genetics*
  • rab GTP-Binding Proteins / genetics*
  • rab7 GTP-Binding Proteins

Substances

  • rab7 GTP-Binding Proteins
  • rab GTP-Binding Proteins

Supplementary concepts

  • Charcot-Marie-Tooth disease, Type 2B