Room-temperature Pd-catalyzed C-H chlorination by weak coordination: one-pot synthesis of 2-chlorophenols with excellent regioselectivity

Chem Commun (Camb). 2014 Feb 7;50(10):1262-4. doi: 10.1039/c3cc47431c.

Abstract

A room-temperature Pd(II)-catalyzed regioselective chlorination reaction has been developed for a facile one-pot synthesis of a broad range of 2-chlorophenols. The reaction demonstrates an excellent regioselectivity and reactivity for C-H chlorination. This reaction represents one of the rare examples of mild C-H functionalization at ambient temperature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chlorine / chemistry*
  • Chlorophenols / chemical synthesis
  • Chlorophenols / chemistry*
  • Halogenation
  • Molecular Structure
  • Palladium / chemistry*
  • Stereoisomerism
  • Temperature*

Substances

  • Chlorophenols
  • Chlorine
  • Palladium
  • 2-chlorophenol