A small molecule two-photon fluorescent probe for intracellular sodium ions

Chem Commun (Camb). 2014 Feb 9;50(11):1309-12. doi: 10.1039/c3cc48342h.

Abstract

We report a small-molecule two-photon fluorescent probe (ANa2) for Na(+) that shows a strong TPEF enhancement in response to Na(+) and can be easily loaded into live cells and can real time monitor the fluctuation of [Na]i in live cells and living tissue at more than 100 μm depth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes
  • Fluorescent Dyes / pharmacology*
  • Glutamic Acid / pharmacology
  • HeLa Cells
  • Heterocyclic Compounds, 1-Ring / pharmacology*
  • Hippocampus / metabolism
  • Histamine / pharmacology
  • Humans
  • In Vitro Techniques
  • Microscopy, Fluorescence, Multiphoton
  • Proline / analogs & derivatives*
  • Proline / pharmacology
  • Rats
  • Sodium / metabolism*

Substances

  • Fluorescent Dyes
  • Heterocyclic Compounds, 1-Ring
  • Glutamic Acid
  • Histamine
  • Proline
  • Sodium