New twist on an ancient innate immune pathway

Immunity. 2013 Dec 12;39(6):1000-2. doi: 10.1016/j.immuni.2013.11.015.

Abstract

Activation of the complement system has long been known to be regulated by a series of steps involving fluid-phase convertases. In this issue of Immunity, Liszewski et al. (2013) report the discovery of an intracellular cathepsin-L-dependent C3 activation pathway.

Publication types

  • Comment

MeSH terms

  • B-Lymphocyte Subsets / cytology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Cathepsin L / metabolism*
  • Cell Differentiation*
  • Complement Activation / physiology*
  • Complement C3 / metabolism*
  • Homeostasis / physiology*
  • Humans

Substances

  • Complement C3
  • CTSL protein, human
  • Cathepsin L