Abstract
The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.
©2013 AACR.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols*
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Computer Simulation
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Databases, Factual
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Evidence-Based Medicine
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Humans
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Molecular Targeted Therapy / methods*
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Neoplasms / drug therapy*
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Neoplasms / genetics*
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Precision Medicine
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Systems Biology / methods*