Inhibition of indoleamine 2,3-dioxygenase by thielavin derivatives from a soil fungus, Coniochaeta sp. 10F058

J Antibiot (Tokyo). 2014 Apr;67(4):331-3. doi: 10.1038/ja.2013.134. Epub 2013 Dec 11.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Ascomycota / classification
  • Ascomycota / isolation & purification
  • Ascomycota / metabolism*
  • Drug Discovery*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology*
  • Fermentation
  • Humans
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / isolation & purification
  • Hydroxybenzoates / metabolism
  • Hydroxybenzoates / pharmacology*
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / antagonists & inhibitors*
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
  • Kinetics
  • Molecular Structure
  • Molecular Typing
  • Mycological Typing Techniques
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / metabolism
  • Neuroprotective Agents / pharmacology*
  • Republic of Korea
  • Soil Microbiology

Substances

  • 4-(4'-(2''-methoxy-4''-hydroxy-3'',6''-dimethylbenzoyloxy)-3',5',6'-trimethyl-2'-methoxybenzoyloxy)-2-methoxy-3,6-dimethylbenzoic acid
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Hydroxybenzoates
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Neuroprotective Agents
  • thielavin F
  • thielavin B