Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant

Biomarkers. 2014 Feb;19(1):63-9. doi: 10.3109/1354750X.2013.867536. Epub 2013 Dec 11.

Abstract

Objective: Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).

Methods: Biomarkers were measured in 67 KTR with AKI caused by different entities.

Results: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / urine*
  • Acute-Phase Proteins / urine*
  • Adult
  • Area Under Curve
  • Biomarkers / urine
  • Creatinine / urine
  • Female
  • Graft Rejection / diagnosis
  • Graft Rejection / epidemiology
  • Graft Rejection / urine*
  • Humans
  • Kaplan-Meier Estimate
  • Kidney Transplantation
  • Lipocalin-2
  • Lipocalins / urine*
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • Prospective Studies
  • Proto-Oncogene Proteins / urine*
  • ROC Curve
  • Risk
  • Treatment Failure

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • LCN2 protein, human
  • Lipocalin-2
  • Lipocalins
  • Proto-Oncogene Proteins
  • Creatinine