Objective: To study the clinical effects of hypoxia preconditioning (HPC) and its effects on serum neuroglobin (NGB) and S-100B level in the patients undergoing intracranial aneurysm surgery.
Methods: Forty patients scheduled to intracranial aneurysm surgery were randomly.divided into 2 groups: HPC group (n= 20) and control group (n= 20). The patients in HPC group were treated with 3 cycles of deoxidation-reoxygenation after intubation. The time of deoxidation in each HPC cycle was recorded, while vital signs were also recorded in each corresponding time point. Blood samples were obtained from exsanguinate radial artery and jugular bulb section at the end of each HPC cycle and corresponding time points during operation to measure serum level of NGB and S100B protein and to analysis blood gas.
Results: During HPC process, the patients in group HPC experienced mild hypoxia and CO2 retention. With the times of HPC increasing, CO2 retention degree became heavier (P<0. 05) while hypoxia improved, the patients need more time to make SpO2 from 100% to 90% (P<0. 05). From T2 to T4 (the end of the third reoxygenation, during skull opened and aneurysm dipped, skull closed), NGB in group HPC was higher than that in control (P<0. 05), but S-100B level was not different between HPC and control group (P>0. 05).
Conclusion: HPC could induce compensatory ability of the body to hypoxia, which might be related to the up-regulation of NGB expression.