Highly active antiretroviral therapy (HAART) has significantly improved the life expectancy of patients with HIV. As a result, kidney transplantation is considered an viable treatment option for HIV infected patients with end stage renal disease. The first living-related kidney transplant in Georgia has been performed between non-identical twin sisters in July 2013. In this paper we give the detailed case report and short overview of the existing literature. This is the first report of the successful kidney transplant in HIV infected patient in East Europe and former Soviet Union Countries including the Central Asia.