Sono-assembly of highly biocompatible polysaccharide capsules for hydrophobic drug delivery

Adv Healthc Mater. 2014 Jun;3(6):825-31. doi: 10.1002/adhm.201300596. Epub 2013 Dec 9.

Abstract

Cells like sugar. General synthesis and potential of intracellular hydrophobic drug delivery of single-component polysaccharide capsules are pursued. The capsules can be generally assembled through hydrogen bonding networks but show striking shell robustness. The evidenced cell internalization, stimuli-responsiveness to local pH changes and high biocompatibilities of the capsules specifically favor their potential intracellular drug delivery.

Keywords: biocompatibility; capsules; hydrophobic drug delivery; polysaccharide; sonochemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism*
  • Capsules / chemistry
  • Capsules / metabolism*
  • Chitosan / chemistry
  • Drug Carriers / chemistry*
  • Fluorescein-5-isothiocyanate / chemistry
  • Fluorescein-5-isothiocyanate / metabolism
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Mice
  • Microscopy, Confocal
  • NIH 3T3 Cells
  • Pharmaceutical Preparations / chemistry
  • Pharmaceutical Preparations / metabolism*
  • Polysaccharides / chemistry*
  • Sonication*
  • Temperature
  • Toluene / chemistry

Substances

  • Biocompatible Materials
  • Capsules
  • Drug Carriers
  • Pharmaceutical Preparations
  • Polysaccharides
  • Toluene
  • Chitosan
  • Fluorescein-5-isothiocyanate