Abstract
Cells like sugar. General synthesis and potential of intracellular hydrophobic drug delivery of single-component polysaccharide capsules are pursued. The capsules can be generally assembled through hydrogen bonding networks but show striking shell robustness. The evidenced cell internalization, stimuli-responsiveness to local pH changes and high biocompatibilities of the capsules specifically favor their potential intracellular drug delivery.
Keywords:
biocompatibility; capsules; hydrophobic drug delivery; polysaccharide; sonochemistry.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biocompatible Materials / chemistry
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Biocompatible Materials / metabolism*
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Capsules / chemistry
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Capsules / metabolism*
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Chitosan / chemistry
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Drug Carriers / chemistry*
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Fluorescein-5-isothiocyanate / chemistry
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Fluorescein-5-isothiocyanate / metabolism
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Hydrogen-Ion Concentration
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Hydrophobic and Hydrophilic Interactions
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Mice
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Microscopy, Confocal
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NIH 3T3 Cells
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Pharmaceutical Preparations / chemistry
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Pharmaceutical Preparations / metabolism*
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Polysaccharides / chemistry*
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Sonication*
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Temperature
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Toluene / chemistry
Substances
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Biocompatible Materials
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Capsules
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Drug Carriers
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Pharmaceutical Preparations
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Polysaccharides
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Toluene
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Chitosan
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Fluorescein-5-isothiocyanate