We report the generation of mid-infrared supercontinua in a step-index fluoroindate-based fiber. The large core of the fluoroindate fiber allows the guiding of multiwatt laser power over a broad spectral range. These fibers exhibit zero dispersion at 1.83 μm, minimal loss of 0.1 dB/m at 3.2 μm up to only 0.8 dB/m at 5 μm. These specifications enable mid-infrared supercontinuum generation and propagation with low loss. By using mid-infrared ultrashort laser pulses from an optical parametric amplifier, we demonstrate generation of a 20 dB spectral flatness supercontinua from 2.7 to 4.7 μm in the fluoroindate fiber, which is twice the spectral broadening compared to a ZBLAN fiber under similar conditions.