The expression of matrix metalloproteinases in placental tissue depends on the severity of undifferentiated connective tissue dysplasia

E A Dubova; I V Klimantsev; K A Pavlov; G V Kulikova; N E Kan; A I Shchyogolev; G T Sukhikh

doi:10.1007/s10517-013-2291-1

The expression of matrix metalloproteinases in placental tissue depends on the severity of undifferentiated connective tissue dysplasia

Bull Exp Biol Med. 2013 Nov;156(1):110-3. doi: 10.1007/s10517-013-2291-1.

Authors

E A Dubova¹, I V Klimantsev, K A Pavlov, G V Kulikova, N E Kan, A I Shchyogolev, G T Sukhikh

Affiliation

¹ V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia. e_dubova@oparina4.ru.

PMID: 24319705
DOI: 10.1007/s10517-013-2291-1

Abstract

Immunohistochemical study of MMP-2 and MMP-9 expression in placental tissue of pregnant patients with undifferentiated connective tissue dysplasia of different severity showed that more severe condition was associated with higher expression of these MMP, this underlying the development of pregnancy and labor complications. The most pronounced elevation of the studied MMP levels was found in the basal plate decidual cells in women with undifferentiated connective tissue dysplasia of more than 18 score.

MeSH terms

Adult
Case-Control Studies
Connective Tissue Diseases / enzymology*
Connective Tissue Diseases / pathology
Female
Humans
Matrix Metalloproteinase 2 / metabolism*
Matrix Metalloproteinase 9 / metabolism*
Organ Specificity
Placenta / enzymology*
Placenta / pathology
Pregnancy
Pregnancy Complications / enzymology*
Pregnancy Complications / pathology
Severity of Illness Index
Young Adult

Substances

MMP2 protein, human
Matrix Metalloproteinase 2
MMP9 protein, human
Matrix Metalloproteinase 9