Microglia specific fluorescent probes for live cell imaging

Chem Commun (Camb). 2014 Feb 4;50(9):1089-91. doi: 10.1039/c3cc45715j.

Abstract

Small molecule fluorescent probes offer significant advantages over conventional antibody and fluorescent protein labeling techniques. Here we present and , dyes that label live microglia specifically. They may be applied to the isolation and imaging of live microglia when investigating their role in neuroinflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Boron Compounds / chemical synthesis
  • Boron Compounds / chemistry*
  • Boron Compounds / metabolism
  • Cells, Cultured
  • Flow Cytometry
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / metabolism
  • Humans
  • Mice
  • Microglia / cytology*
  • Microglia / metabolism
  • Microscopy, Confocal / methods*
  • Optical Imaging*
  • Phagocytosis

Substances

  • Boron Compounds
  • CDr10a compound
  • CDr10b compound
  • Fluorescent Dyes