[Valproate-induced hyperammonemic encephalopathy in a neonate: treatment with carglumic acid]

An Pediatr (Barc). 2014 Oct;81(4):251-5. doi: 10.1016/j.anpedi.2013.09.015. Epub 2013 Dec 4.
[Article in Spanish]

Abstract

Valproate-induced hyperammonemic encephalopathy (VHE) is an unusual and serious complication of valproate (VA) treatment. When an early diagnosis is made, it can be reversed with VA withdrawal and early treatment for hyperammonemia. We describe the case of a 20 days old male, who developed a serious VHE after receiving VA for refractory neonatal seizures. The VHE was resolved with VA withdrawal in association with carglumic acid and other measures for hyperammonemia treatment.

Keywords: Adverse effect; Carglumic acid; Efecto adverso; Hiperamoniemia; Hyperammonemia; Infant; Neonato; Newborn; Valproate; Valproico; Ácido carglúmico ;.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anticonvulsants / adverse effects*
  • Glutamates / therapeutic use*
  • Humans
  • Hyperammonemia / chemically induced*
  • Hyperammonemia / drug therapy*
  • Infant, Newborn
  • Male
  • Neurotoxicity Syndromes / drug therapy*
  • Neurotoxicity Syndromes / etiology*
  • Seizures / drug therapy
  • Valproic Acid / adverse effects*

Substances

  • Anticonvulsants
  • Glutamates
  • carglumic acid
  • Valproic Acid