Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes

Danilo B Medinas; Claudio Hetz

doi:10.1016/j.cmet.2013.11.009

Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes

Cell Metab. 2013 Dec 3;18(6):771-2. doi: 10.1016/j.cmet.2013.11.009.

Authors

Danilo B Medinas¹, Claudio Hetz

Affiliation

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Molecular Studies of the Cell, Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

PMID: 24315366
DOI: 10.1016/j.cmet.2013.11.009

Abstract

Altered insulin signaling and neuroinflammation are emerging features of Alzheimer's disease. Lourenco et al. (2013) identify a pathogenic mechanism that is shared between Alzheimer's disease and diabetes and contributes to memory loss through a common molecular event: the control of protein synthesis by PKR and the downstream phosphorylation of eIF2α.

Publication types

Comment

MeSH terms

Amyloid beta-Peptides / toxicity*
Animals
Brain / drug effects*
Insulin Receptor Substrate Proteins / metabolism*
Polymers / toxicity*
Tumor Necrosis Factor-alpha / metabolism*
eIF-2 Kinase / metabolism*

Substances

Amyloid beta-Peptides
Insulin Receptor Substrate Proteins
Polymers
Tumor Necrosis Factor-alpha
eIF-2 Kinase