A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU

Exp Toxicol Pathol. 2014 Mar;66(2-3):125-8. doi: 10.1016/j.etp.2013.11.003. Epub 2013 Dec 4.

Abstract

Background: Schwannoma is a tumor of the nervous system composed by Schwann cells. It can occur naturally in several tissues of the body in both humans and animals. Diaphragmatic hernia can be congenital or acquired and is defined as a protrusion of abdominal viscera into the thoracic cavity.

Materials and methods: The animal was a female rat from an experiment of mammary tumor chemically induced. It was injected with N-methyl-N-nitrosourea (MNU) and died spontaneously at 22 weeks of age.

Results: The animal had a diaphragmatic hernia and a hemorrhagic and multicystic mass in the liver herniated lobule. Microscopically the liver displayed a well circumscribed mass that was a tumor with hemorrhagic areas, necrosis and Antoni A and Antoni B patterns. It also displayed occasional positivity to vimentin and diffuse positivity to S-100 and NSE.

Conclusion: The tumor was a schwannoma with the origin in the Glisson's capsule.

Keywords: Diaphragmatic hernia; NSE; Rat; S-100 protein; Schwannoma; Vimentin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Hernia, Diaphragmatic / complications*
  • Hernia, Diaphragmatic / pathology
  • Liver Neoplasms, Experimental / chemically induced*
  • Liver Neoplasms, Experimental / complications
  • Liver Neoplasms, Experimental / pathology
  • Methylnitrosourea / toxicity*
  • Neurilemmoma / chemically induced*
  • Neurilemmoma / complications
  • Neurilemmoma / pathology
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Methylnitrosourea