Abstract
The objective of this paper was to study the therapeutic effect of Stigma maydis polysaccharides in diabetic mice. Mouse models of types 1 and 2 diabetes were established. The body weight, food intake, water intake as well as blood sugar level and glucose tolerance of mice were measured. Stigma maydis polysaccharides can improve the symptoms of weight loss and polydipsia in diabetic mice, and had an obvious antagonistic effect on alloxan-induced hyperglycaemia. The glucose tolerance test also showed that the Stigma maydis polysaccharides had very good effects on suppression and prevention of acute hyperglycaemia. Stigma maydis polysaccharides have some improvement effect on alloxan-induced types 1 and 2 diabetes.
Keywords:
Stigma maydis polysaccharides; hypoglycaemia; ultrasonic extraction.
MeSH terms
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Experimental / blood
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Diabetes Mellitus, Experimental / drug therapy*
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Diabetes Mellitus, Type 1 / blood
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Diabetes Mellitus, Type 1 / drug therapy
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy
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Disease Models, Animal
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Flowers / chemistry
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Glucose Tolerance Test
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Hyperglycemia / blood
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Hyperglycemia / drug therapy*
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use*
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Male
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Mice
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Mice, Inbred Strains
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Phytotherapy*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Polydipsia / drug therapy
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Polydipsia / etiology
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Polysaccharides / pharmacology
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Polysaccharides / therapeutic use*
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Weight Loss / drug effects
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Zea mays / chemistry*
Substances
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Blood Glucose
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Hypoglycemic Agents
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Plant Extracts
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Polysaccharides