Abstract
Cholera toxin, methylisobutylxanthine and prostacyclin (PGI2) analogues as well as dibutyryl cyclic AMP inhibit by 2-7-fold 3H-thymidine uptake into intimal cells isolated from atherosclerotic human aorta in primary culture. These agents also decrease cholesteryl ester and triglyceride levels and do not affect content of phospholipids and free cholesterol in cells cultured from atherosclerotic lesions.
MeSH terms
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1-Methyl-3-isobutylxanthine / pharmacology*
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Aorta / metabolism*
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Arteriosclerosis / metabolism*
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Bucladesine / pharmacology
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Cell Division / drug effects
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Cholera Toxin / pharmacology*
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Cyclic AMP / metabolism*
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Epoprostenol / pharmacology*
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Humans
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In Vitro Techniques
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Lipids / analysis
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Theophylline / analogs & derivatives*
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Thymidine / metabolism
Substances
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Lipids
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Bucladesine
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carboprostacyclin
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Cholera Toxin
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Theophylline
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Epoprostenol
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Cyclic AMP
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1-Methyl-3-isobutylxanthine
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Thymidine