Objective: To explore the expression pattern of inflammatory cytokines at various inflammatory levels of adamantinomatous craniopharyngioma by cytokine antibody array.
Methods: The inflammatory levels of adamantinomatous craniopharyngioma were evaluated on the basis of the number of inflammatory cells at the interface of tumor and normal tissues. And the expression of inflammatory cytokines was examined at various inflammatory levels of adamantinomatous craniopharyngioma by inflammatory cytokine antibody array and the results were verified by Western blot.
Results: Compared with the mild inflammatory group, the levels of inflammatory cytokines of severe inflammatory group markedly increased, including pro-inflammatory cytokines, chemokines and cytokine receptors.
Conclusion: Antibody array demonstrates a significant change in cytokine profiles in adamantinomatous craniopharyngioma with severe inflammation, as compared with those with mild inflammation.