Role of multiligand/RAGE axis in platelet activation

Thromb Res. 2014 Mar;133(3):308-14. doi: 10.1016/j.thromres.2013.11.007. Epub 2013 Nov 16.

Abstract

In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end products (AGEs) significantly increases platelet activation and receptor for AGEs (RAGE) expression at the platelet surface membrane. In addition to AGEs, other ligands (S100, HMGB1 and amyloid β, among others) of RAGE have raised particular attention in platelet activation. Therefore, in this article we describe platelet hyperactivity by AGEs via RAGE-independent and RAGE-dependent pathways.

Keywords: AGEs; HMGB1; Platelets; RAGE; S100.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Platelets / metabolism
  • Blood Platelets / physiology*
  • Glycation End Products, Advanced / blood*
  • Humans
  • Ligands
  • Platelet Activation / physiology*
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic / blood*

Substances

  • Glycation End Products, Advanced
  • Ligands
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic