New cytotoxic apotirucallanes from the leaves of Walsura trichostemon

Jirapast Sichaem; Suttira Khumkratok; Pongpan Siripong; Santi Tip-pyang

doi:10.1007/s11418-013-0808-6

New cytotoxic apotirucallanes from the leaves of Walsura trichostemon

J Nat Med. 2014 Apr;68(2):436-41. doi: 10.1007/s11418-013-0808-6. Epub 2013 Dec 1.

Authors

Jirapast Sichaem¹, Suttira Khumkratok, Pongpan Siripong, Santi Tip-pyang

Affiliation

¹ Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.

PMID: 24293387
DOI: 10.1007/s11418-013-0808-6

Abstract

Three new apotirucallanes (1-3) were isolated from the leaves of Walsura trichostemon. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their cytotoxicity against KB and HeLa cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / toxicity
Cell Line, Tumor
HeLa Cells
Humans
Meliaceae / chemistry*
Plant Leaves / chemistry
Triterpenes / chemistry*
Triterpenes / toxicity

Substances

11,25-dideacetyltrichostemonate
21,24,25-triacetyl-7-deacetyl-6-hydroxylbrujavanone E
7-deacetylbrujavanone E
Antineoplastic Agents
Triterpenes
apotirucallane