GC models for separation optimization in pressure-tunable tandem capillary columns operated isothermally: part 2: control experiments using a new capillary column interface

Abstract

In the previous part of this study, a significant improvement of the fundamental relationships that control GC resolution in a pressure-tunable assembly operating in isothermal conditions inside a single oven was made. A theoretical approach for the correct choice of the working temperature was proposed for the first time. In this second part of our report, a new interfacing device has been proposed for a rapid and reliable alignment of the two columns at the midpoint junction. Moreover, the results of a series of experimental tests have confirmed the validity of the proposed mathematical models.

Keywords: Capillary column interface; Control experiments; Selectivity tuning; Tandem column chromatography.