Autism susceptibility genes and the transcriptional landscape of the human brain

Shingo Miyauchi; Irina Voineagu

doi:10.1016/B978-0-12-418700-9.00010-1

Autism susceptibility genes and the transcriptional landscape of the human brain

Int Rev Neurobiol. 2013:113:303-18. doi: 10.1016/B978-0-12-418700-9.00010-1.

Authors

Shingo Miyauchi¹, Irina Voineagu

Affiliation

¹ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. Electronic address: i.voineagu@unsw.edu.au.

PMID: 24290390
DOI: 10.1016/B978-0-12-418700-9.00010-1

Abstract

Autism is the most severe end of a spectrum of neurodevelopmental conditions, autism spectrum disorders (ASD). ASD are genetically heterogeneous, and hundreds of genes have been implicated in the etiology of the disease. Here, we discuss the contribution of brain transcriptome studies in advancing our understanding of the genetic mechanisms of ASD and review recent work characterizing the spatial and temporal variation of the human brain transcriptome, with a focus on the relevance of these data to autism susceptibility genes.

Keywords: Autism; Brain development; Genetics; Genomics; Transcriptome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autistic Disorder / genetics*
Autistic Disorder / pathology*
Brain / growth & development
Brain / metabolism*
Genetic Predisposition to Disease*
Humans
Transcriptome