Electropolymerization of curcumin on glassy carbon electrode and its electrocatalytic application for the voltammetric determination of epinephrine and p-acetoaminophenol

Abstract

Here in, we report the simultaneous voltammetric determination of epinephrine (EP) and p-acetoaminophenol (AP) on a poly curcumin (1,7 Bis ((4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5 dione), poly CM) modified glassy carbon electrode (GCE) for the first time. The CM was polymerized on to the GCE surface by simple electro polymerization process. A low peak to peak (ΔEp) separation of 60 mV was observed, indicating fast electron transfer between poly CM and the electrode surface. The electrochemical measurements and surface morphology of the as prepared poly CM film modified electrode were studied using cyclic voltammetry (CV), and field emission scanning electron microscopy (SEM), respectively. Moreover, poly CM modified GCE exhibits enhanced electro catalytic activity toward EP and AP in the linear range of 4.97-230.76 μM and 0.99-230.76 μM and with very low detection limit (LOD) of 0.05 μM and 0.1 μM. The sensitivity is 0.621 and 0.303 μAμM(-1)cm(2) for EP and AP, respectively. The practical feasibility of the proposed poly CM/GCE was evaluated in adrenaline injection (1 mg mL(-1)) solutions and paracetamol tablets for the simultaneous determination of EP and AP. We found maximum recovery of 99.2% for adrenaline injection and 97.4% for paracetamol tablets. Finally the modified electrode exhibit excellent repeatability, reproducibility and stability for the selective and simultaneous determination of EP and AP.

Keywords: Epinephrine; Poly curcumin; p-Acetoaminophenol and real sample.