Abstract
The syntheses of [(3) H]SCH 444877, [(2) H4 ]SCH 444877, and [(14) C]SCH 444877 are described. [(3) H]SCH 444877 was prepared in three steps from tritium gas. [(2) H4 ]SCH 444877 was synthesized from [(2) H4 ]ethanolamine in four steps with an overall yield of 40%. [(14) C]SCH 444877 was prepared from barium [(14) C]cyanamide in 10 steps with an overall yield of 8.1%.
Keywords:
PDE 5 inhibitor; SCH 444877; carbon-14; deuterium; synthesis; tritium.
Copyright © 2013 John Wiley & Sons, Ltd.
MeSH terms
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Carbon Radioisotopes / chemistry
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Chemistry Techniques, Synthetic
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Deuterium / chemistry*
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Guanine / analogs & derivatives*
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Guanine / chemical synthesis
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Guanine / chemistry
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry*
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Isotope Labeling
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Phosphodiesterase 5 Inhibitors / chemical synthesis*
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Phosphodiesterase 5 Inhibitors / chemistry*
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Reference Standards
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Tritium / chemistry*
Substances
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3-(3-chloro-4-methoxybenzyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-5-ethyl-7,8-dihydro-3H-imidazo(2,1-b)purin-4(5H)-one
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Carbon Radioisotopes
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Imidazoles
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Phosphodiesterase 5 Inhibitors
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Tritium
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Guanine
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Deuterium