Carbon-14 labelled tribendimidine, a broad-spectrum anthelmintic drug

Erminia Fontana; Alberto Pignatti; Alberto Ghiglieri; Rosangela Battaglia; Flavio Cinato; Chong Wang; Eugenio de Hostos

doi:10.1002/jlcr.3070

Carbon-14 labelled tribendimidine, a broad-spectrum anthelmintic drug

J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):471-4. doi: 10.1002/jlcr.3070. Epub 2013 Jul 9.

Authors

Erminia Fontana¹, Alberto Pignatti, Alberto Ghiglieri, Rosangela Battaglia, Flavio Cinato, Chong Wang, Eugenio de Hostos

Affiliation

¹ Accelera S.r.l., viale Pasteur 10, 20014, Nerviano, MI, Italy; Isotope Chemistry, Accelera S.r.l., viale Pasteur 10, 20014, Nerviano, MI, Italy.

PMID: 24285523
DOI: 10.1002/jlcr.3070

Abstract

The preparation of [(14) C]tribendimidine, a broad-spectrum anthelmintic agent related to amidantel, and its use during excretion and metabolism studies in the rat are described in this paper.

Keywords: ADME; carbon-14; rat; tribendimidine.

MeSH terms

Animals
Anthelmintics / chemistry*
Anthelmintics / metabolism
Carbon Radioisotopes / chemistry
Isotope Labeling
Male
Phenylenediamines / chemistry*
Phenylenediamines / metabolism
Rats
Rats, Sprague-Dawley

Substances

Anthelmintics
Carbon Radioisotopes
Phenylenediamines
tribendimidine