Polyethylene glycol (PEG-400): an efficient and recyclable reaction medium for the synthesis of pyrazolo[3,4-b]pyridin-6(7H)-one derivatives

Molecules. 2013 Oct 24;18(11):13139-47. doi: 10.3390/molecules181113139.

Abstract

A mild and efficient synthesis of pyrazolo[3,4-b]pyridine-6(7H)-one derivatives via a three-component reaction of an aldehyde, Meldrum's acid and 3-methyl-1H-pyrazol-5-amine using recyclable polyethylene glycol (PEG)-400 as a reaction medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and begin environmentally friendly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Dioxanes / chemistry
  • Polyethylene Glycols / chemistry*
  • Pyrazoles / chemistry
  • Pyridines / chemistry*

Substances

  • 1H-pyrazol-5-amine
  • Aldehydes
  • Dioxanes
  • Pyrazoles
  • Pyridines
  • Polyethylene Glycols
  • Meldrum's acid
  • pyridine