CO-releasing binuclear rhodium complexes as inhibitors of nitric oxide generation in stimulated macrophages

Inorg Chem. 2013 Dec 16;52(24):13806-8. doi: 10.1021/ic401967g. Epub 2013 Nov 27.

Abstract

Nontoxic CO-releasing dirhodium complexes act as inhibitors of NO in stimulated macrophage cells, suggesting that novel antiinflammatory treatments could involve the use of these types of binuclear complexes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology*
  • Biological Assay
  • Carbon Monoxide / chemistry
  • Carbon Monoxide / metabolism*
  • Cell Line
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Humans
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Models, Biological
  • Nitric Oxide / antagonists & inhibitors*
  • Rhodium / chemistry
  • Rhodium / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Coordination Complexes
  • Nitric Oxide
  • Carbon Monoxide
  • Rhodium