New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions?

Gastroenterology. 2014 Jan;146(1):24-6. doi: 10.1053/j.gastro.2013.11.023. Epub 2013 Nov 22.

Authors

Janel L Kopp¹, Maike Sander²

Affiliations

¹ Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, California.
² Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, California. Electronic address: masander@ucsd.edu.

PMID: 24275238
DOI: 10.1053/j.gastro.2013.11.023

No abstract available

Publication types

Editorial
Comment

MeSH terms

Animals
Bile Ducts / cytology*
Carcinoma in Situ / metabolism*
Carcinoma, Pancreatic Ductal / metabolism*
Carcinoma, Pancreatic Ductal / pathology*
Cell Transformation, Neoplastic / pathology*
Doublecortin-Like Kinases
HMGB Proteins / metabolism*
Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Pancreatic Ducts / pathology*
Pancreatic Neoplasms / metabolism*
Pancreatic Neoplasms / pathology*
Precancerous Conditions / pathology*
Protein Serine-Threonine Kinases / metabolism*
SOXF Transcription Factors / metabolism*
Stem Cells / metabolism*

Substances

HMGB Proteins
Intracellular Signaling Peptides and Proteins
SOXF Transcription Factors
Sox17 protein, mouse
DCLK1 protein, human
Doublecortin-Like Kinases
Dclk1 protein, mouse
Protein Serine-Threonine Kinases