Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity

L P Churilov; Yu I Stroev; I Yu Serdyuk; O M Kaminova-Mudzhikova; I V Belyaeva; A N Gvozdetsky; N A Nitsa; L R Mikhailova

doi:10.1016/j.pathophys.2013.11.002

Autoimmune thyroiditis: Centennial jubilee of a social disease and its comorbidity

Pathophysiology. 2014 Jun;21(2):135-45. doi: 10.1016/j.pathophys.2013.11.002. Epub 2013 Nov 22.

Authors

L P Churilov¹, Yu I Stroev², I Yu Serdyuk², O M Kaminova-Mudzhikova², I V Belyaeva², A N Gvozdetsky², N A Nitsa³, L R Mikhailova⁴

Affiliations

¹ Medical Faculty, Saint Petersburg State University, Russia. Electronic address: elpach@mail.ru.
² Medical Faculty, Saint Petersburg State University, Russia.
³ Medical Faculty, Saint Petersburg State University, Russia; Research Institute of Phthisiopulmonology, Saint Petersburg, Russia.
⁴ Research Institute of Phthisiopulmonology, Saint Petersburg, Russia.

PMID: 24274975
DOI: 10.1016/j.pathophys.2013.11.002

Abstract

The history of autoimmune thyroiditis (AIT) and its role in pathophysiology of transition from adolescent hypothalamic syndrome (obesity with rose striae) into early metabolic syndrome is reviewed. Marfanoid phenotype and chronic disequilibrium between local, autacoid-mediated and systemic, hormone-mediated regulation, typical for inherited connective tissue disorders, may promote this transition. Pathogenetic roles of hyperprolactinemia and cytokine misbalance are evaluated and discussed in its pathogenesis.

Keywords: Adolescents; Autoimmune thyroiditis; Cytokines; Leptin; Marfanoid phenotype; Metabolic syndrome; Obesity; Prolactin; Transforming growth factor.

Publication types

Review