Pulchranins B and C, new acyclic guanidine alkaloids from the Far-Eastern marine sponge Monanchora pulchra

Tatyana N Makarieva; Ekaterina K Ogurtsova; Yuliya V Korolkova; Yaroslav A Andreev; Irina V Mosharova; Ksenya M Tabakmakher; Alla G Guzii; Vladimir A Denisenko; Pavel S Dmitrenok; Hyi-Seung Lee; Eugene V Grishin; Valentin A Stonik

Pulchranins B and C, new acyclic guanidine alkaloids from the Far-Eastern marine sponge Monanchora pulchra

Nat Prod Commun. 2013 Sep;8(9):1229-32.

Authors

Tatyana N Makarieva¹, Ekaterina K Ogurtsova, Yuliya V Korolkova, Yaroslav A Andreev, Irina V Mosharova, Ksenya M Tabakmakher, Alla G Guzii, Vladimir A Denisenko, Pavel S Dmitrenok, Hyi-Seung Lee, Eugene V Grishin, Valentin A Stonik

Affiliation

¹ G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok-22, Prospect 100-let Vladivostoku 159, Russia. makarieva@piboc.dvo.ru

PMID: 24273853

Abstract

New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 microM, respectively) and less potent against TRPV3 and TRPA1 receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Animals
Guanidines / chemistry
Guanidines / isolation & purification*
Molecular Structure
Pacific Ocean
Porifera / chemistry*
TRPV Cation Channels / antagonists & inhibitors*

Substances

Alkaloids
Guanidines
TRPV Cation Channels
pulchranin B
pulchranin C